Computational Scientist I/II (Genomics)

Employer
Frederick National Laboratory
Location
Frederick, MD
Posted
Nov 24, 2021
Closes
Nov 26, 2021
Ref
222414548
Function
Accountant, IT
Industry
Science
Hours
Full Time
PROGRAM DESCRIPTION The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha's major activities include development and application of genomic assay platforms for use in DCTD-sponsored national clinical trials and preclinical studies. KEY ROLES/RESPONSIBILITIESWe are seeking an enthusiastic, creative, and collaborative computational scientist to support computational and biological related questions in assigned projects/programs:Develop, validate and maintain genomic analysis pipelines generated from the MoCha lab and/or collaborator(s)Interact with PIs to define strategies for genomic data analysis including hypothesis generation and testing of predictive biomarkers of drug responseProvide biological interpretation of the genomic analysis to advance the understanding of cancerSupervise and collaborate with other bioinformatics team members to ensure the quality of work and the prioritization of projects to meet deadlinesBe responsible for generating scientific opinions, identifying potential resources or constraints, and proposing strategies for exploiting available databases and program data generated at the molecular and cellular levelsInteract extensively with intramural laboratories at the NIH and extramural scientists and present the findings to PIsBASIC QUALIFICATIONSThis position may be filled at the Computational Scientist I or II level.To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:Possession of a Doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation in biomedical science/bioinformatics/math/statistics/computer-related discipline. Foreign degrees must be evaluated for US equivalency Computational Scientist I - No work experience required with a Doctorate degreeComputational Scientist II - a minimum of two (2) years of progressively responsible scientific and/or complex system management/bioinformatics experienceExtensive experience in analysis of next generation sequencing (NGS) data (including quality metrics, mapping, variant calling, quantitation of gene expression and biological interpretation)Experience managing large datasets and computational tasks in a Linux-based high-performance computing environment and cloud environmentProficiency with Bash, Python, Perl, R, C/C++, and/or JAVA and bioinformatics tools and database managementExperience with Snakemake, make, or other workflow management systemsStrong computational/bioinformatics skills and demonstrated ability to work with scientists to deliver on objectives in defined timelines are requiredIndependence, self-motivation, innovation and ability to excel in a goal-oriented, multifaceted and fast-moving team environment are requiredExperience and demonstrated success in a team-oriented environment and excellent communication skills (written and oral); ability to organize and execute multiple projects in parallelMust be able to obtain and maintain a security clearanceThis position is essential to the success of MoCha and on-site presence in Frederick, MD and occasionally in Shady Grove (Rockville, MD) is required. PREFERRED QUALIFICATIONSCandidates with these desired skills will be given preferential consideration:Peer reviewed publications demonstrating knowledge of the biology of cancerExperience with Ion Torrent systems, including the Ion Reporter systemExperience with variant review and QC control in a CLIA certified laboratory

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