Genomics Specialist

Frederick National Laboratory
Rockville, MD
Jun 16, 2021
Jun 19, 2021
Accountant, IT
Full Time
Scientist III, Functional Genomics Lead Job ID: req1819 Employee Type: exempt full-time Facility: Rockville: 9615 MedCtrDr Location: 9615 Medical Center Drive, Rockville, MD 20850 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. Our core values of accountability, compassion, collaboration, dedication, integrity, and versatility serve as a guidepost for how we do our work every day in serving the public's interest. Position Overview: PROGRAM DESCRIPTION The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the NCI's Division of Cancer Epidemiology and Genetics (DCEG), the world's most comprehensive cancer epidemiology research group. CGR is located at the NCI-Shady Grove campus in Gaithersburg, MD and operated by Leidos Biomedical Research, Inc. We care deeply about discovering the genetic and environmental determinants of cancer, and new approaches to cancer prevention, through our contributions to the molecular, genetic, and epidemiologic research of the 70+ investigators in DCEG. Working in concert with epidemiologists, biostatisticians, and basic research scientists in DCEG's intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. This includes the design and analysis of high throughput studies using various types of '-omics' technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis, and molecular epidemiologic studies based on novel assays focused on the metabolome and microbiome. KEY ROLES/RESPONSIBILITIES Within CGR, the Functional Group supports DCEG investigators with project specific laboratory services, including a wide variety of genomic, functional, and cell-based assays. We are recruiting for a scientist / team lead for the functional team within CGR. The successful candidate will have responsibility for the day-to-day supervision of the functional team and tasked with delivering high quality molecular and cell-based services to support epidemiological cancer research at the DCEG. He/she must demonstrate scientific and technical leadership for the team and horizon scanning for future technologies, as well as establishing, maintaining, and monitoring the key performance indicators of the team. This position will work collaboratively with all areas of CGR and the Laboratory of Translational Genomics (LTG) of the DCEG. Responsible for day to day activities of the functional team within CGR Sets and maintains overall standards for the quality of service, technical reproducibility, and accuracy Works seamlessly and collaboratively with CGR and LTG laboratory experts, LIMS, QA, project management, and bioinformatics resources at CGR to address functional needs of our DCEG collaborators Thoughtfully synthesize results into clear presentations and concise summaries of work Routinely provide project updates to investigators and solicit feedback on next steps from a broad array of internal experts Advises researchers on selection and application of available functional technologies; anticipates future requirements and develops service accordingly Ensure proper documentation of ongoing work for all future DCEG manuscripts and project tracking Utilizes extensive knowledge of the technology to advise users and PIs with respect to experimental design, implementing SOPs, and determining best practices Collaborate closely with DCEG PIs on scientific manuscript development, submission, and revision activities with significant co-authorship and potentially first authorship opportunities Interview, select, coach, mentor, and develop staff BASIC QUALIFICATIONS To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: Possession of a PhD degree from an accredited college or university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for US equivalency In addition to the education requirement, a minimum of five (5) years of related biomedical experience Extensive cell culture experience - cloning, cell-based assays, stable cell line development, primary cell culture, knock in/out/down Experience with CRISPR techniques Experience with confocal microscopy Biochemistry experience - protein assays, protein expression, western blots, immunoassay (ELISA / Luminex), Immunoprecipitation / co-IP and ChIP Extensive molecular biology experience - PCR, qPCR, NGS techniques Experience with delivering highly complex scientific information to a broad range of researchers Proven ability to engage with a wide variety of stakeholders, including academics (internal and external research group leaders and their teams), technical staff, researchers Strong organizational skills with the ability to multitask Strong written and oral communication skills Analytical skills to resolve problems that require basic scientific or technical principles Working knowledge of Windows-based computer operating systems and Microsoft office suite Ability to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration: A minimum of three (3) years of experience supervising or leading teams or projects Experience with single cell techniques, experimental design Experience with flow cytometry Bioinformatics skills Cancer biology subject matter expert Experience with negotiation and influence with researchers, service providers, vendors Experience with managing, training, and mentoring staff to work effectively as a team to deliver scientific research programs Experience with prioritization in a high-pressure environment JOB HAZARDS This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations This position is subject to the environmental conditions such as working outdoors, high humidity areas indoors, dampness and chilling, dry atmospheric conditions, etc. as part of the job Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW) #readytowork by Jobble