In Vivo Scientist, Oncology Research

Gaithersburg, MD
Dec 02, 2020
Dec 04, 2020
Analyst, Research
Full Time
What is Happening at AstraZenecaAt AstraZeneca, we turn ideas into life changing medicines. Working here means being ambitious, thinking big and working together to make the impossible a reality. Were passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new insights to life.Oncology VisionAstraZenecas vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers.This OpportunityWe are seeking a highly motivated and independent Scientist in cancer pharmacology with a track record of scientific excellence in the area of in vivo cancer modelling, to join our Antibody-Drug Conjugates (ADCs) Portfolio team within AZ Early Oncology Discovery in Gaithersburg, MD USA. As a Scientist you will be a key member of a team focused on delivering all aspects of in vivo pharmacology support for our ADC portfolio. You will bring your theoretical and practical expertise to establish assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline.Site DescriptionOur Gaithersburg, Maryland facility develops life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 3000 experts in our field, and it is only a short drive from Washington, DC. It is filled with cutting edge technology. Our work areas were built to facilitate teamwork, safe interactions and cross functional science. We believe employees who feel safe and are challenged by the work, are positioned to be creatively inspired to deliver.Main Activities and ResponsibilitiesWorking in this laboratory-based position within Oncology Research you will develop, design, conduct and analyze both in vivo and in vitro experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics. You will be expected to support cross-functional teams and work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals.As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modelling and have a genuine passion for this field of research. Education RequirementsScientist BS/MS in Biology, Pharmacology or other related scientific discipline with 3-6 yrs. relevant scientific experienceNecessary Skills and Experience RequiredExperience developing and working with complex in vivo models, such as xenograft, patient derived xenograft (PDX), syngeneic and autochthonous mouse models.Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.Experience with a range of in vitro skills, eg cell culture, molecular biology, immunoblotting, flow cytometry and ELISA.Works independently, assesses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment.Excellent communication and presentation skillsA proven track record of high productivity and scientific publications in peer reviewed journals.Desirable for the roleBiotechnology or pharmaceutical industry experience preferred but not required.Why AstraZeneca?At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means were opening new ways to work, groundbreaking cutting edge methods and bringing unexpected teams together. Interested? Come and join our Jobble

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