The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.KEY ROLES/RESPONSIBILITIES Support a range of NCI RAS Initiative projects encompassing global, targeted, and/or quantitative proteomics Assist with sample preparation and data acquisition/analysis for bottom-up and middle-down proteomic applications Assist with method development for improved proteoform characterization and PTM localization on an Orbitrap Fusion Lumos Contribute to RAS proteoform assay expansion to encompass a broad range of cell, tissue, and cancer contexts Support the daily operation and routine maintenance of three Orbitrap-based mass spectrometers and accompanying LC platforms Report, present, and publish research findings BASIC QUALIFICATIONS Possession of a Ph.D. degree in Chemistry, Biochemistry, Molecular Biology, or a related field from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for US equivalency Prior experience in sample preparation, data acquisition, and data analysis for tandem MS/MS and/or top-down proteomics (with accompanying publication record) Demonstrated ability to independently carry out experimental procedures, balance changing priorities, and perform troubleshooting to ensure timely project completion Ability to master novel technologies, workflows, and instrumentation Must be able to obtain and maintain a security clearance PREFERRED QUALIFICATIONS Prior experience in top-down proteomic applications (global and targeted), instrumentation, and data analysis Prior experience in protein purification, protein biochemistry, and molecular biology Prior experience in operating and maintaining Orbitrap-based instruments JOB HAZARDS OR REQUIREMENTS Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)