Research Associate, Metabolomics Shared Resource, Lombardi Comprehensive Cancer Center - Georgetown

Location
Washington D.C.
Posted
Mar 22, 2018
Closes
Jul 12, 2018
Function
Analyst, Research
Industry
Research
Hours
Full Time
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Requirements

Research Associate, Metabolomics Shared Resource, Lombardi Comprehensive Cancer Center - Georgetown University Medical Center

Georgetown Lombardi Comprehensive Cancer Center (LCCC) clinicians are dedicated to providing the best professional care, delivered with compassion, for all patients.  Lombardi's internationally-renowned physicians treat virtually every type of cancer, including breast, lung, colorectal, prostate, head and neck, and cancers of the blood.  Along with cutting-edge cancer care, we offer a program of innovative clinical trials and a full range of supportive care services to improve our patients' health and quality of life.

The Research Associate strengthens the activities of high through-put metabolomics core facility and the center of innovation for metabolomics at Georgetown University Medical Center (GUMC). S/he monitors a very specialized service in the MSR, namely “Ultra-performance liquid chromatography - multiple reaction monitoring mass spectrometry (UPLC-MRM-MS) for small molecule quantitation in addition to NMR spectroscopy.”  The Research Associate contributes to high profile clinical trial projects, as well as biomarker validation studies, using stable isotope dilution multiple reaction monitoring mass spectrometry for pharmacodynamic and pharmacokinetic studies; and develops quantitative workflows for small molecules to facilitate projects in and across GUMC. Reporting to the Co-Director, the Research Associate has duties that include but are not limited to:

Research

  • Provides Ultra-performance liquid chromatography - multiple reaction monitoring mass spectrometry (UPLC-MRM-MS) for small molecule quantitation service to more than 45 investigators across GUMC and beyond.
  • Participates, along with the Core Director, in project consultation sessions requiring intellectual input about study design, experimental conditions, data analysis strategies, and expected outcomes.
  • Performs method and assay development using different column chemistries and extraction procedures using solid phase and liquid-liquid extraction techniques.
  • Performs large scale targeted quantitation studies to support biomarker discover and validation in compliance with the GLP guidelines.
  • Uses advanced bioinformatics software for data pre- and post-processing, as well as for multivariate data and analysis.
  • Assists the Core Director with methodology and data analysis write ups for grants and manuscripts for PIs using MSR services.
  • Develops and expands MSR capabilities for broader class of endogenous metabolite quantitation for biomedical research.

Laboratory Administration

Performs support responsibilities such as scheduling Mass spectrometry instrument operations and maintenance, data backup on a UIS drive, maintaining laboratory in compliance with safety procedures, ordering and reconciling the ProCard monthly statement, initiating requisitions through GMS; and assuring general laboratory upkeep that includes autoclaving, scheduling waste disposal, update of chemical inventory.

Requirements

  • Master's in Engineering, Computer Science, Chemistry/Biochemistry, Bioinformatics, or related field - Doctoral degree preferred
  • 1 year of relevant experience in biochemistry, mass spectrometry, and mass spectrometry data analysis  
  • Experience and a deep understanding of small molecule chemistry for designing and developing mass spectrometric assays for specific molecules using targeted approach
  • Proficiency in software-based pre- and post-processing of MS data in order to successfully contribute to several different projects and manuscripts
  • Expertise in processing samples for triple quadrupole Mass Spectrometry
  • Expertise in small molecule chemistry, analytical chemistry, statistics and bioinformatics
  • Experience in developing mass spectrometry based quantitative small molecule assays
  • Experience in analysis of SID-MRM-MS mass spectrometry data
  • Familiarity with GLP and GMP guidelines for MRM-MS assays
  • Experience in the laboratory duties described
  • Experience in quantitative and qualitative statistical analyses and tests
  • Familiarity with GLP and GMP guidelines for MRM-MS assays
  • Good communication skills - both verbal and written
  • Ability to multi-task
  • Preference for experience in analysis of large volume and high dimensional data sets

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EEO Statement:

Georgetown University is an Equal Opportunity/Affirmative Action Employer fully dedicated to achieving a diverse faculty and staff.  All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, national origin, age, sex (including pregnancy, gender identity and expression, and sexual orientation), disability status, protected veteran status, or any other characteristic protected by law.

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