This position is responsible for providing overall toxicology expertise in the Cosmetic Ingredient Review (CIR), supporting the development and implementation of a coordinated approach to the safety assessment of cosmetic ingredients that 1) maximizes the number of ingredients in each report and 2) bolsters the overall weight of evidence with regard to safety conclusions on cosmetic ingredients. Such approaches may include, but are not limited to, the use of structure/activity relationships (SAR) and consideration of chemical groups with similar toxicological properties (e.g., read across approaches) or relevant calculations (e.g., threshold of toxicological concern evaluations, quantitative risk assessments, margin of safety, etc.).
In addition to supporting the implementation of this coordinated approach, the position is responsible for spearheading the use of computational, or in silico, tools for review by the CIR Expert Panel and future integration into safety assessments. Beginning with the implementation of currently available computational programs (e.g., OECD QSAR Toolbox), and building the CIR Expert Panel’s confidence in the use of such tools, the incumbent will also lead efforts conducted by technical vendors to further develop a CIR Chemistry and Toxicology Database & Workflows.
Reasonable Accommodations Statement
To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. Reasonable Accommodations may be made to enable qualified individuals with disabilities to perform the essential functions.
Essential Functions Statement(s)
- Provides toxicology expertise within CIR.
- Develops strategies to implement the use of SAR, read across approaches, and aggregate approaches, with emphasis on biological activity, for the safety assessment of cosmetic ingredients. These approaches should not only maximize the number of ingredients in reports developed by CIR staff, but bolster the overall weight of evidence of such safety profiles.
- Undertakes the development of cosmetic ingredient safety assessments of high profile concern. Reviews abstracts, selects which full versions of relevant studies to retrieve, and writes comprehensive, accurate, clear, and concise summaries of the collected literature. As available, analyzes and incorporates clear and concise summaries of unpublished data received. Follows all duties of scientific writers comprising the development of safety assessments (e.g., ensuring that toxicological summaries include all relevant points and accurately reflect the studies therein).
- Attends Expert Panel meetings and engages in the review for all assessments. Although CIR writers are expected to be knowledgeable about their reports and able to interact with the Panel to identify data gaps, to respond to questions regarding available or needed data, and assist the Panel in developing languages to express ideas under discussion, the incumbent toxicologist defends the scientific content of all CIR reports at those meetings, when needed. The incumbent also ensures that CIR staff are well prepared in advance of CIR Expert Panel meetings.
- Revises and edits reports prepared by scientific writers in a timely way, before and after each meeting, ensuring that the specific, technical opinions of the CIR Expert Panel members are accurately reflected in those revisions and edits.
- Represents CIR at professional meetings, and documents such meetings and other contacts.
- Other duties may be assigned as needed.
- Communication, Written - Strong writing and presentation skills, with the ability to analyze and condense complex information.
- Accountability - Ability to accept responsibility and account for his/her actions.
- Accuracy - Ability to perform work accurately and thoroughly.
- Analytical Skills - Ability to use thinking and reasoning to solve a problem.
- Autonomy - Ability to work independently with minimal supervision.
- Coaching and Development - Ability to provide guidance and feedback to help others strengthen specific knowledge/skill areas.
- Communication, Oral - Ability to communicate effectively with others using the spoken word.
- Detail Oriented - Ability to pay attention to the minute details of a project or task.
- Goal Oriented - Ability to focus on a goal and obtain a pre-determined result.
- Leadership - Ability to influence others to perform their jobs effectively and to be responsible for making decisions.
- Organized - Possessing the trait of being organized or following a systematic method of performing a task.
- Project Management - Ability to organize and direct a project to completion.
- Time Management - Ability to utilize the available time to organize and complete work within given deadlines.
- Other duties as assigned
SKILLS & ABILITIES
Education : A PhD in toxicology or related discipline,
Experience : Four to ten years related
Computer Skills: MS Office & computational programs (e.g., OECD QSAR Toolbox)
Certificates & Licenses: DABT certification or DABT eligible
Experience in implementation of SAR, read-across, or similar toxicological approaches and computational toxicological tools and methodologies.
Work is performed in a non-smoking office setting, with occasional travel.
Email resumes should be sent to email@example.com