Scientist I- Toxin Vaccine Research

Frederick, MD
Aug 16, 2017
Sep 27, 2017
Analyst, Research
Research, Science
Full Time
The Contractor will conduct basic and applied research on current and emerging threats at BSL2 and BSL3 levels, in support of the biodefense and infectious disease program at USAMRIID. The Contractor will work in a range of biophysical methods supporting prophylactic and therapeutic product development for MCM against botulinum and ricin toxins. The contractor shall provide laboratory support with laboratory experiments in BSL-2/3 CDC registered laboratories and thus must hold and maintain BPRP status, IAW the provisions in this contract and applicable regulations.


The contractor will be the lead technical POC and PI for the production and purification of recombinant protein vaccine antigens and immunotherapeutics. This include the operation and maintenance of small scale bioreactors and the development of custom FPLC methodology to purify native and recombinant biological molecules as needed, 7-10 products per year.


Contractor will be responsible for designing methodology and protocols needed to perform biophysical characterization of custom biologicals as well commercial and in-house produced toxin preparations used in support of the vaccine and immunotherapeutic efforts. This will include supervising and instructing laboratory technician personnel in basic and advanced techniques of biochemical and biophysical characterization including SDS-PAGE, Western blotting, endotoxin quantification assays, scanning UV spectroscopy, and dynamic light scattering.


The contractor will be responsible for performing molecular biology techniques to develop synthetic and native chimeric gene constructs for recombinant protein expression if microbiological production platforms. This includes site-directed DNA mutagenesis techniques for the purpose of protein engineering to increase yield or modify biochemical characteristics of the encoded recombinant proteins.


As the lead POC for recombinant production work, the contractor will be responsible for training personnel on the operation and maintenance of laboratory equipment. The contractor will coordinate all maintenance, trouble shooting, and repairs of equipment with the appropriate vendor and medical maintenance staff. The contractor will ensure that all operations of the laboratory are compliant with all applicable safety and Biosurety regulations.


The Contractor will assist in the preparation of technical reports, standard operating procedures, and manuscripts relating to their research efforts. The contractor is expected to present research findings at one scientific conference per year. Contractor will present results in written and oral format publicly and internally.


Contractor will prepare monthly Toxin Vaccine Progress Report.

Education Bachelors Degree in a scientific discipline. M.S. or Ph.D highly preferred.

Qualifications 2-5 years of related experience in scientific research, analysis and/or engineering.

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