General Dynamics IT is seeking a Biomaterials/Formulations Chemist to support the following research project at the Naval Medical Research Unit in San Antonio Texas.Project Description: The long-term goal of the project is to develop a wound dressing that is simple, stable, and effective at preventing and treating established infections in combat-injured personnel. The project involves investigation of novel antimicrobial peptides as therapeutics for broad spectrum activity against military relevant multi-drug resistant fungal and bacterial biofilm infections and development of a wound dressing for sustained delivery of the peptides to topical infections. Responsibilities: In collaboration with principal investigators, plan and execute biomedical research toward the development of novel therapeutics in the field of dental and craniofacial health for the United States warfighter. Serve as a subject matter expert in biomaterials and formulations chemistry. Develop new ideas and proposals for internal and external funding. Provide writing support for protocol-driven research proposals, animal use protocols, human use protocols, peer-reviewed manuscripts, and internal reports. Prepare abstracts and present posters and oral presentations at professional and technical meetings. Required Knowledge, Skills, and Abilities:
- Formulate novel therapeutic biomaterials and characterize their physicochemical and biological properties including stability, drug release kinetics, biocompatibility, and biodegradation.Fabricate biodegradable dressings and scaffolds containing therapeutics including antimicrobials and wound healing agents.Experience with strategies to stabilize formulations, increase biocompatibility, increase payload, and control drug delivery.Provide support in development of appropriate in vitro and in vivo model systems. Evaluate biomaterials for efficacy using appropriate research models, such as in vitro and in vivo models for infection control, wound healing, and tissue regeneration.Experience with advanced materials characterization techniques such as UV-Vis, FTIR, XRD, HPLC, SEM, and TEM.Experience with electrospinning, topical formulations for sustained drug delivery, polymeric formulations, and peptide-based therapeutics is a plus.Ability to perform basic statistics, including but not limited to power analysis and ANOVA.Experience in using MSWord, MSPowerPoint, MSExcel spreadsheets, and graphing software such as GraphPad Prism or SigmaPlot.Ability to multi-task and work in a team environment.
- Ph.D. in chemistry, materials science and engineering, polymer sciences, biomedical engineering, chemical engineering or related discipline.
- Must be a US CitizenPrefer 1 – 2 years of post-doctoral fellowship completed.