Scientist IV Microbiology

6 days left

Location
Frederick, MD
Posted
Jul 28, 2017
Closes
Aug 26, 2017
Function
IT
Industry
Science
Hours
Full Time
The Principle Investigator will conduct research on specified bacterial threats; in support of the biodefense and infectious disease program. The Principle investigator will work in BSL-3 and BSL-4 laboratories and thus must hold and maintain BPRP status; IAW the provisions in this contract and applicable regulations.

 Specific Responsibilities Include:

 
  • Present 2 research findings/presentations at lab meetings and attend 2 scientific meetings or symposia per year
  • Complete 4 quarterly reports and 1 annual progress report for DTRA
  • Prepare one 1st author manuscript for publication per year
  • Prepare supporting author scientific papers for publication.
  • Conduct transcriptome analyses to better understand bacterial pathogenesis and design vaccines and therapeutics.
  • Create 6 non-BSAT strains for the production of Bacillus anthracis capsule
  • Add capsule operon and other control elements in Bacillus anthracis Live Attenuated Vaccine strains
  • PCR reactions for genetic confirmation of strains.
  • Create genetic knockouts in Francisella tularensis and Bacillus anthracis for vaccine studies
  • Make and characterize mutant bacterial strains
  • Perform MSD protein assays
  • Plan and assist with animal experiments.
  • Prepare DNA/RNA from bacteria and tissues
  • Prepare BSL2; BSL3 labs for quarterly and annual Safety; Bio-surety and CDC inspections
  • Run ELISA tests to support anthrax vaccine studies. Run ELISAs and other tests [gel electrophoreses] to quantitate and analyze B. anthracis capsule to support anthrax vaccine studies
  • Write; plan and execute animal protocols to evaluate experimental anthrax vaccines.
  • Prepare spores for animal challenges for analysis of animal immune response to vaccine.
  • Complete approximately bacterial opsonization assays to evaluate experimental anthrax vaccines.
  • Conduct Equipment Inventory Management twice a year in BSL-2 and BSL-3
Education Masters Degree in a scientific discipline. Preferred- PhD in bacteriology

Qualifications
  • 8-10 years of related experience in scientific research; analysis and/or engineering. Preferred- 10-15 years of related experience in a research laboratory setting.
  • Experience managing a research laboratory including technicians and other junior scientists is desired. 
  • SSBI required if work will be conducted in biocontainment laboratories
  • Demonstrated their subject matter expertise in a number of areas; and the ability to conduct team-based research through publication of several technical reports and/or peer-reviewed publications
  • Excellent written and oral communication skills
  • Must be eligible for enrollment in the Army Biological Personnel Reliability Program (BPRP)
 As a trusted systems integrator for more than 50 years, General Dynamics Information Technology provides information technology (IT), systems engineering, professional services and simulation and training to customers in the defense, federal civilian government, health, homeland security, intelligence, state and local government and commercial sectors.With approximately 32,000 professionals worldwide, the company delivers IT enterprise solutions, manages large-scale, mission-critical IT programs and provides mission support services.GDIT is an Equal Opportunity/Affirmative Action Employer - Minorities/Females/Protected Veterans/Individuals with Disabilities.

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