Manager, Pathology Laboratory (NCI)

Leidos Biomedical Research, Inc.
Gaithersburg, MD
Jun 16, 2017
Jun 21, 2017
Full Time
PROGRAM DESCRIPTION The Cancer Genomics Research Laboratory (CGR) investigates the contribution of germline and somatic genetic variation to cancer susceptibility and outcomes in support of the National Cancer Institute (NCI)'s Division of Cancer Epidemiology and Genetics (DCEG). Working in concert with epidemiologists, biostatisticians and basic research scientists in DCEG's intramural research program, CGR provides the capacity to conduct genome-wide discovery studies and targeted regional approaches to identify the heritable determinants of various forms of cancer. This includes the design and analysis of high throughput studies using various types of "-omics" technologies such as array- and sequence-based genome-wide association studies, studies of tumor characteristics using integrated genomic data analysis and molecular epidemiologic studies based on novel metabolomic and microbiomic assays. JOB DESCRIPTION/BASIC FUNCTIONThis position description does not represent a current opening but may be used to identify candidates with skills and experience for positions within Leidos Biomedical Research that frequently become available. Candidates who express an interest may be considered for future positions at Leidos Biomedical Research. DCEG maintains a rich resource of tissue specimens from a diverse array of cancer types to enable these studies. Included in its over 12 million biospecimen collection, DCEG currently stores over 300,000 tissue specimens from 275 family- and population-based studies, with formalin-fixed, paraffin-embedded (FFPE) tissues stored as blocks, cores, tissue microarrays (TMAs), and slides. CGR is establishing a new laboratory section that will support the following activities: histology and cytology, immunohistochemistry, In situ hybridization, TMA construction, fluorescence microscopy, laser capture microdissection (LCM), and extraction of nucleic acids from fresh frozen and FFPE tissues. This new area will be tightly integrated with existing CGR capabilities, including somatic genomic analyses and bioinformatics. This position is for the manager of the wet pathology laboratory section and will be located in Gaithersburg, MD. The successful candidate will have responsibility for establishing laboratory capabilities in support of DCEG molecular pathology studies, which will be phased in as DCEG research priorities demand. Concurrently, identification of external resources (including other Leidos Biomedical Research laboratories, contract research organizations, academic partners) to supplement internal capabilities is planned, and the Manager will need to coordinate this work alongside CGR project management staff and DCEG investigators. General responsibilities include: Work seamlessly and collaboratively with technology development, LIMS, QA, project management, laboratory and informatics resources at CGR in order to fully integrate new functions of molecular pathology into existing organization. Work within CGR's existing quality management framework to set and maintain overall standards for the quality of service, technical reproducibility and accuracy, to include development of standard operating protocols and routine quality assurance and quality control checks Identify equipment needs, select and implement, including establishment of appropriate use and maintenance protocols Working within CGR's existing LabVantage LIMS and with the support of CGR LIMS programmer analysts, establish workflows that support selection of appropriate protocols and capture of required metadata Perform laboratory duties including tissue microtomy, macro- and microdissection, H&E staining and slide QC, immunohistochemistry, and in situ hybridization Establish and execute extraction of nucleic acids from a variety of starting materials, including fresh frozen tissue, FFPE slides, scrolls and cores Work with project management staff to track progress and completion and communicate effectively with DCEG collaborators Work closely with pathologists, CGR and DCEG scientists to identify, research and implement new techniques, including assay development and validation, and performance qualification of existing validated assays Coordinate with existing digital pathology section for improvements in laboratory staining protocols and optimization of new protocols Hire, train, develop and manage staff effectively BASIC QUALIFICATIONSTo be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below: Possession of a Master's degree, PhD preferred from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) appropriate to biomedical research (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for US equivalency A minimum of eight (8) years of experience including two (2) or more years of managerial experience is required. Extensive experience in histopathology techniques, including histology sectioning, special stains, immunohistochemistry, in situ hybridisation. Ability to read slides and evaluate staining patterns and quality independently or with minimal assistance Experience in extraction of nucleic acids from fresh frozen and FFPE derived materials Experience in assay development and optimization, with proven capabilities in monitoring laboratory results for adherence to quality acceptance criteria Ability to work and communicate effectively with scientific staff at multiple levels Proven ability to organize and prioritize multiple projects in a demanding scientific environment Must be able to obtain and maintain a security clearance PREFERRED QUALIFICATIONSCandidates with these desired skills will be given preferential consideration: American Society for Clinical Pathology Certification Experience with design, creation and analysis of TMAs Familiarity with image analysis software Experience with automated laboratory equipment for staining and extraction Experience with Laboratory Information Management Systems