Antiparasitic Drug Testing Technician (WRAIR Experimental Therapeutics)

Silver Spring, MD
Jun 14, 2017
Sep 25, 2017
Specialty Trades
Full Time
GDIT is seeking a Antiparasitic Drug Testing Technician to support the mission of the Experimental Therapeutics (ET) Branch of the Walter Reed Army Institute of Research (WRAIR).  The mission of the WRAIR Branch of Experimental Therapeutics is to discover and develop new pharmaceutical agents to protect military members from death, disease, and injury. The ET Branch is organized into three distinct departments which contribute to the different phases leading to FDA drug approval. The three comprising departments are the Departments of Drug Discovery, Drug Development, and Clinical Pharmacology.

This position is in direct support of the Department of Drug Discovery. Specific tasks include:

    Provide support to the in vivo antiparasitic testing by managing the blood collection and drug formulation for antimalarial efficacy and leishmanial pharmacokinetics.
    Perform animal studies as designed in approved IACUC protocols to assess antiparasitic drugs using liver-stage efficacy using in vivo imaging system (IVIS), blood-stage efficacy (Thompson Test), animal models for antileishmanial drug testing, and pharmacokinetic testing.
    Generate reports from in vivo studies that are suitable for upload into a LIMS system.
    Prepare and administer drug formulations of antiparasitic drugs for various animal studies in toxicity studies, pharmacokinetic, and efficacy studies using multiple routes of administration.
    Collect and properly prepare blood samples from animal studies as part of antiparasitic drug testing models.
    Maintain in vitro malaria cultures to support toxicity and efficacy in vivo studies.
    Assist in isolation and viability assessment of malaria sporozoites from mosquito salivary gland.
    Maintain a safe working environment and adhere to applicable safety regulations.
    Assist with the preparation of IACUC protocols and amendments as required.
    Have RLATG - Registered Laboratory Animal Technologist, RLAT - Registered Laboratory Animal Technician (AALAS), and ALAT - Assistant Laboratory Animal Technician (AALAS) certifications.
    Perform clinical observations in the animal models.
    Analyze and summarize experimental data from the imaging system for reports, publications, and presentations, as required.
    Ensure that all lab equipment is maintained and serviced as required.
Physical Capabilities: Work may involve long periods of standing and handling of BSL2 level infectious agents, toxic chemicals, and blood-borne pathogens. Work will require the ability to operate research equipment requiring manual dexterity. The ability to handle research animals is also needed.


Work environment: Biosafety Level (BSL) 2 laboratory and animal BSL 2 laboratory. Potential exposure to infectious agents, toxic chemicals, and blood-borne pathogens. Must be able to wear appropriate personal protective equipment. Will also work in an office setting.

Education Bachelor's Degree in a scientific or technical discipline, or the equivalent combination of education, professional training, or work experience.

Qualifications 3-5 years of related scientific experience.

  As a trusted systems integrator for more than 50 years, General Dynamics Information Technology provides information technology (IT), systems engineering, professional services and simulation and training to customers in the defense, federal civilian government, health, homeland security, intelligence, state and local government and commercial sectors.With approximately 32,000 professionals worldwide, the company delivers IT enterprise solutions, manages large-scale, mission-critical IT programs and provides mission support services.GDIT is an Equal Opportunity/Affirmative Action Employer - Minorities/Females/Protected Veterans/Individuals with Disabilities.