Antibacterial Drug Technicina (WRAIR Experimental Therapeutics)
GDIT is seeking a antibacterial drug technician to support the mission of the Experimental Therapeutics (ET) Branch of the Walter Reed Army Institute of Research (WRAIR). The mission of the WRAIR Branch of Experimental Therapeutics is to discover and develop new pharmaceutical agents to protect military members from death, disease, and injury. The ET Branch is organized into three distinct departments which contribute to the different phases leading to FDA drug approval. The three comprising departments are the Departments of Drug Discovery, Drug Development, and Clinical Pharmacology.This position is in direct support of the Department of Drug Discovery. Specific tasks include:
- Provide in vitro and in vivo support to the testing of drug-resistant antibacterial screens.Perform animal studies as described in approved IACUC protocols to assess antibacterial drug efficacy, toxicity, and pharmacokinetics using the appropriate animal models.Prepare drug formulations of antibacterial drugs for various animal toxicity, pharmacokinetic, and efficacy studies.Perform relevant in vitro assays in accordance with the Experimental Therapeutics Branch’s Antibacterial Testing strategy, to include in vitro activity screening and minimum inhibitory concentration (MIC) evaluation of candidate compounds.Keep accurate and complete records of research done in accordance with the QASP and contract requirements.Prepare cultures of pertinent BSL 2 bacterial pathogens to be used in in vivo and in vitro experiments as directed by WRAIR investigators, in accordance with the applicable health and safety guidelines.Maintain adequate inventories of laboratory and other supplies, and prepare purchase requests for supplies when needed.Assist with maintaining and preparing all required SOPs, and any applicable IACUC reports and documents.Assist in all aspects of the CARB program as described in the Presidential Initiative.Maintain a safe working environment and adhere to applicable safety regulations.Ensure that all lab equipment is maintained and serviced as required.Physical Capabilities: Physical Capabilities: Work may involve long periods of standing and handling of BSL2 level infectious agents, toxic chemicals, and blood-borne pathogens. Work will require the ability to operate research equipment requiring manual dexterity. Work environment: Biosafety Level (BSL) 2 laboratory and animal BSL 2 laboratory. Potential exposure to infectious agents, toxic chemicals, and blood-borne pathogens. Must be able to wear appropriate personal protective equipment. Will also work in an office setting.