Toxicology Pharmacokinetic Asessment Tech

Location
USA, Maryland, Silver Spring
Posted
May 11, 2017
Closes
Jun 15, 2017
Ref
2017-23830
Contact
General Dynamics
Function
Analyst, Research
Industry
Research
Hours
Full Time

GDIT is seeking a Toxicology and pharmacokinetic assessment technician (In Vitro Core) to support the mission of the Experimental Therapeutics (ET) Branch of the Walter Reed Army Institute of Research (WRAIR). The mission of the WRAIR Branch of Experimental Therapeutics is to discover and develop new pharmaceutical agents to protect military members from death, disease, and injury. The ET Branch is organized into three distinct departments which contribute to the different phases leading to FDA drug approval. The three comprising departments are the Departments of Drug Discovery, Drug Development, and Clinical Pharmacology.



This position is in direct support of the Department of Drug Discovery.


  • Provide support for in vivo pharmacokinetic studies in rodent and non-human primates.
  • Prepare various oral and injectable drug formulations for all efficacy studies.
  • Perform single or multiple dose range studies of oral or injected antimalarial compounds assessing drug metabolism in animal models, using multiple routes of administration.
  • Perform animal blood sampling from tail vein weekly.
  • Collect and assess clinical observation from animal studies with regard to general toxicity evaluation (body weight loss, behavior activity, urine excretion, e.g.).
  • Perform pharmacokinetic studies in rhesus monkey (dosing, blood sampling, sample analysis).
  • Report to the PI results, clinical observations, and data from various studies and establish Standard Operation Procedures (SOP) for each study and record data in computer databases for further evaluation and development.
  • Assist in the maintenance of 2 laboratories and various equipment items.
  • Assist with supply maintenance including inventory regulation, proper disposal, and requesting new items to maintain laboratory functions.
  • Assist with establishing animal models such as gametocyte models and assays and humanized-mouse models for antiparasitic drug testing.





Physical Capabilities: Work may involve long periods of standing and handling of BSL2 level infectious agents, toxic chemicals, and blood-borne pathogens. Work will require the ability to operate research equipment requiring manual dexterity. The ability to handle research animals is also needed.



Work environment: Biosafety Level (BSL) 2 laboratory and animal BSL 2 laboratory. Potential exposure to infectious agents, toxic chemicals, and blood-borne pathogens. Must be able to wear appropriate personal protective equipment. Will also work in an office setting.




BS in Microbiology, biomedical field or related field.




2-5 years of related experience in scientific research, analysis and/or engineering.



As a trusted systems integrator for more than 50 years, General Dynamics Information Technology provides information technology (IT), systems engineering, professional services and simulation and training to customers in the defense, federal civilian government, health, homeland security, intelligence, state and local government and commercial sectors.With approximately 32,000 professionals worldwide, the company delivers IT enterprise solutions, manages large-scale, mission-critical IT programs and provides mission support services.GDIT is an Equal Opportunity/Affirmative Action Employer - Minorities/Females/Protected Veterans/Individuals with Disabilities.