Lead Synthetic Chemist - Experimental Therapeutics

Silver Spring, MD
May 02, 2017
Sep 25, 2017
Full Time
GDIT is seeking a Lead Synthetic Chemist to support the mission of the Experimental Therapeutics (ET) Branch of the Walter Reed Army Institute of Research (WRAIR). The mission of the WRAIR Branch of Experimental Therapeutics is to discover and develop new pharmaceutical agents to protect military members from death, disease, and injury. The ET Branch is organized into three distinct departments which contribute to the different phases leading to FDA drug approval. The three comprising departments are the Departments of Drug Discovery, Drug Development, and Clinical Pharmacology.

This position is in direct support of the Department of Drug Development. Specific tasks include:

    Design routes of chemical synthesis for designed analogs directed toward specific therapeutic targets
    Synthesize new anti-microbial analogs in support of a lead optimization program as directed by the medicinal chemists.
    Assign synthetic targets to synthetic chemists as requested by the government or senior medicinal chemist.
    Serve as a mentor and lead chemist to the synthetic organic chemists, soldiers, and students working in the synthesis lab.
    Provide input for the performance evaluations of senior synthetic organic chemists and synthetic organic chemists.
    Register, submit, and validate compounds registered in the LIMS.
    Prepare and present project status presentations and/or written reports as required.
    Attend meetings and professional conferences as needed.
    Preside over bi-weekly meetings between key administrative and technical staff to set performance tasks, report progress, and troubleshoot technical issues.


Knowledge Base: Experience with drug development laboratory management skills. Previous work for a government agency or pharmaceutical industry. Working knowledge of organic synthesis. Understanding of chemical synthesis route design, understanding of heteroaryl and heterocyclic chemical synthesis, drug design, drug discovery process, purification techniques, chemical reaction troubleshooting and ability to analyze target compound spectra obtained by analytical instruments to characterize compounds such as 1D and 2D nuclear magnetic resonance (NMR), infrared spectrometry (IR), mass spectrometry (MS), and elemental analysis. Experience with a suitable chemical mapping analysis software program. Experience with publishing scientific papers in a peer reviewed recognized medicinal/chemistry journals and/or patents. Experience mentoring junior chemists.


Physical Capabilities: Work may involve long periods of standing and handling of numerous chemicals and/or hazardous materials.

Work Environment: Laboratory/office environment; may require working evenings and weekends.

Education Ph.D. in organic chemistry, medicinal chemistry, or related discipline.

Qualifications 10-15 years of related experience in scientific research, analysis and/or engineering.

  As a trusted systems integrator for more than 50 years, General Dynamics Information Technology provides information technology (IT), systems engineering, professional services and simulation and training to customers in the defense, federal civilian government, health, homeland security, intelligence, state and local government and commercial sectors.With approximately 32,000 professionals worldwide, the company delivers IT enterprise solutions, manages large-scale, mission-critical IT programs and provides mission support services.GDIT is an Equal Opportunity/Affirmative Action Employer - Minorities/Females/Protected Veterans/Individuals with Disabilities.