Scientist RAS 3D Cell Culture (NCI)

Leidos Biomedical Research, Inc.
Frederick, MD
Apr 13, 2017
Apr 21, 2017
Accountant, IT
Full Time
PROGRAM DESCRIPTIONThe Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish National Cancer Institute (NCI) research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. JOB DESCRIPTION/BASIC FUNCTIONThe Scientist I will work in support of the Frederick National Laboratory/NCI RAS Initiative in Frederick, Maryland. One of the major objectives of the RAS initiative at the Frederick National Lab for Cancer Research (FNLCR) is to dissect the biology and mechanisms that result in oncogenic signaling KRAS mutant cells in support of drug discovery efforts. The Scientist I using primarily 3D cell culture systems will: 1) work to expand knowledge of RAS signaling pathways, 2) participate in experimental design and to independently conduct experiments in a priority-driven environment, 3) complete projects independently and as part of a team, 4) be responsible for timely updates of the project progress to their supervisor both informally and by formal report writing, 5) generate high-quality peer-reviewed publications, 6) be responsible for formal reporting of data including presentations and/or publications and, and 7) stay abreast of current research techniques and remain knowledgeable in pertinent areas through reading literature and by attending scientific presentations. To learn more about the RAS Initiative at the Frederick National Lab, please visit: For information regarding Dr. Rachel Bagni, Sr. Scientist, Cancer Research Technology Program, and her lab, please visit: PLEASE NOTE THAT LEIDOS BIOMEDICAL RESEARCH, INC. CANNOT HIRE J-1 VISA HOLDERS FROM THE NATIONAL INSTITUTES OF HEALTH.BASIC QUALIFICATIONSTo be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:PhD in a field related to pharmaceutical science, medicinal chemistry, or chemistry, or in a related discipline from an accredited college or university according to the Council for Higher Education Accreditation (CHEA) appropriate to biomedical research, or eight (8) years of experience in lieu of degreeForeign degrees must be evaluated for US equivalencyNo experience required beyond the educational requirementKnowledge of cell biology and signal transduction pathwaysAbility to perform basic molecular biology experiments both independently and as a part of the RAS team in pursuit of specific research goals and objectivesKnowledge and ability to generate and characterize engineered cell lines used to study oncogenic signalingCell culture and cell-based assay development experienceMust be able to obtain and maintain a Security ClearancePREFERRED QUALIFICATIONSCandidates with these desired skills will be given preferential consideration:Background in oncology and experience with in vitro cancer cell modelsExperience with 3D cell culture model systems and 3D cell-based assaysFamiliarity with the relevant scientific literatureAbility to develop and modify methods and techniques independently