Scientist, Imaging Sciences

AstraZeneca PLC
Gaithersburg, MD
Jun 24, 2022
Jul 09, 2022
Accountant, IT
Full Time
Lab Scientist with clinical and/or research experience in immunohistochemistry and biomarker analysis.Do you have expertise in, and passion for, immunohistochemistry and biomarker analysis? Would you like to apply your expertise to impact patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.Clinical Pharmacology and Safety Sciences (CPSS) is changing the way imaging technologies are combined to offer unprecedented insight and impact. Our imaging hubs combines data from histology, digital pathology, multiplex assays, advanced molecular imaging techniques (including mass spectrometry imaging) and a full suite of in vivo imaging technologies.As part of our team, you will have the opportunity to be involved in the investigation of both the safety and efficacy of drugs within our projects in both a preclinical and clinical setting. We believe this is a truly exciting opportunity for a hardworking Image Analysis Scientist.Position Summary:The Scientist position is a hands-on laboratory position responsible for performing all tasks associated with tissue staining including but not limited to Immunohistochemistry (IHC), immunofluorescence (IF), multiplexed IHC/IF, and in situ hybridization. The Scientist will support assay development, optimization and validation, utilizing immunohistochemical (IHC) and in situ hybridization (ISH) techniques. The Scientist will also perform slide imaging, assay interpretation and documentation, and will work closely with pathologists and team members to provide the highest quality assay performance in support of experimental research and clinical (GCP) projects.Major Duties and Responsibilities (including supervising others): Performs routine and non-routine slide/tissue staining including but not limited to IHC, IF, in situ hybridization and histology procedures Develops, optimizes and validates tissue staining protocols. Responsible for the correct operation and utilization of lab equipment, and overall state of the shared lab space. Performs slide digitization and evaluates images and re-scans as needed for highest quality image production in adherence with established SOPs. Ensures proper management of research, pre-clinical and clinical human tissue following company's HBS guidelines. Makes detailed observations, analyzes data, interprets results, and communicates findings to team members in a clear and concise manner. May be asked to present findings at internal and external meetings. Provides solutions to a variety of problems involving basic scientific principles. Works in compliance with Good Laboratory Practices (GLP) and Good Clinical Laboratory Practices (GCLP) regulations Maintains up to date training in GLP in support of toxicology studies and GCLP in support of clinical trials. Adhere to the highest laboratory standards including safety and company Code of Conduct. Prepares documentation and packages for shipment Performs routine and non-routine histology including but not limited to histology, grossing, processing, embedding, microtomy, and staining Communicates results to team members and is involved in the interpretation of data. Assesses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery May contribute to preparation of manuscripts and/or patent applications. Shares relevant external published papers with peers Prepares and maintains precise technical summaries, protocols and all appropriate documentation of experiments in laboratory notebooks/electronic laboratory notebooks. Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations. Establish working relationships and credibility with department members and others within, and possibly outside, the company. Performs other duties as assignedRequirements/Qualifications:Education Required:Minimum Bachelors' degree in the biological sciences, Masters preferred.Experience Required: Must have >1 year direct experience in Immunohistochemistry Experience using automated IHC staining platforms preferred Multiplex staining, immunofluorescence and in situ hybridization experience preferred Proficient in use of relevant computer programs (Microsoft Office, Excel and MS Project)Desirable for the role Experience using automated IHC staining platforms preferred Multiplex staining, immunofluorescence and in situ hybridization experience preferred Biopharmaceutical industry, hospital or academic experience Understanding of immunology/pathology Excellent oral and written communication skillsLevel of Supervision Required:Perform job duties with minimal supervisionWhy AstraZeneca?At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.Where can I find out more?Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram Posted16-May-2022Closing Date17-Jul-2022AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.AstraZeneca has taken critical steps to protect colleagues, loved ones, and patients from COVID-19 and its variants. Accordingly, AstraZeneca requires all US employees to be fully vaccinated for COVID-19 prior to the first date of employment. AstraZeneca will consider requests for reasonable accommodations as required by applicable law.