Mass Spectrometry Proteomics CLIA Scientist

Frederick National Laboratory
Frederick, MD
Jul 02, 2022
Jul 09, 2022
Accountant, IT
Full Time
Mass Spectrometry Proteomics CLIA ScientistJob ID: req2290Employee Type: exempt full-timeDivision: Cancer Research Technology ProgramFacility: ATRF: OtherLocation: 8560 Progress Drive, Frederick, MD 21701 USAThe Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc. The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.Position Overview:PROGRAM DESCRIPTIONThe Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy, and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.KEY ROLES/RESPONSIBILITIESDevelop, validate, and implement CLIA mass spectrometry (MS)-based proteomics assays to support clinical assay development.Operate and maintain state-of-the-art LC-MS triple quadrupole instrument in a CLIA laboratory environment.Comprehensive data analysis using variety of different methods and software, such as Skyline.Develop new proteomics and data analytical methods as needed.Summarize and present key results at project reviews meetings and contribute and write manuscripts for per review publications.BASIC QUALIFICATIONSTo be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:Possession of a Ph.D. degree in biochemistry, analytical chemistry or other related discipline from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education).No experience required beyond education requirement.More than three years of MS-based proteomic experience in mass spectrometry proteomics.Solid understanding of separation chemistry for proteins/peptides analysis with an experience of nano-flow HPLC/UPLC.Extensive experience in sample preparation, LC-MS operation, troubleshooting, QC, standardization for proteomics workflow.Strong theoretical understanding of both global and targeted mass spectrometry proteomics and bioinformatic methods to interpret and validate findings.Experience using MS software suites for proteomics workflow analysis, such as Xcalibur, free style, Skyline, etc.Ability to obtain and maintain a clearance.PREFERRED QUALIFICATIONS Candidates with these desired skills will be given preferential consideration:Experience performing MRM or immuno-MRM experiments strongly preferred.Two (2) years of related post graduate MS-based proteomic experience.Experience operating a SciEx Citrine triple quadrupole MS.Experience working in a highly regulated laboratory environment, such as a CLIA laboratory.Familiarity with CLIA laboratory requirements.JOB HAZARDSThis position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations.Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)#readytoworkSDL2017

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